Diethylphosphite → HCID 19084809, compound

HRID 962408Notes

Reaction equation

HRID 962408 reaction equation
[O:1]=[C:2]([CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[P:17]([O-:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20]>>[CH2:19]([O:18][P:17]([O:21][CH2:22][CH3:23])([C:2]([OH:1])([CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:24])[CH3:20]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 19084812HCID 19084812, compound

Product 1

HCID 19084809HCID 19084809, compound

Procedure

A mixture of 3.36 g (0.01 mole) of ethyl 2-oxo-4-(2-pyridylamino)butanoate in 6.9 g (0.05 mole) of diethyl phosphite is stirred at 20°-30° for 4 days. The excess diethyl phosphite is removed under vacuum on a rotary evaporator, and the crude product is purified by flash chromatography on silica gel using chloroform/ethanol as eluant.

Workup

  1. customThe excess diethyl phosphite is removed under vacuum on a rotary evaporator
  2. customthe crude product is purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-6f08ba2ebc674cc79e95cfdb7cfdb6cf
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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