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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 962412Generated: November 1, 2026

Diethylphosphite → Ethyl 2-Diethoxyphosphinyl-4-(2-(N,N-dimethylamino)ethylthio)-2-hydroxybutanoate

https://huagongshe.com/reaction/962412

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethylphosphiteHCID 3780918—
Reactantethyl 4-(2-(N,N-dimethylamino)ethylthio)-2-oxobutanoateHCID 19084768—
ProductEthyl 2-Diethoxyphosphinyl-4-(2-(N,N-dimethylamino)ethylthio)-2-hydroxybutanoateHCID 19084837—

Reaction Steps

A mixture of 2.33 g (0.01 mole) of ethyl 4-(2-(N,N-dimethylamino)ethylthio)-2-oxobutanoate in 6.9 g (0.05 mole) of diethyl phosphite was stirred at 20°-30° for 4 days. The excess diethyl phosphite is removed under vacuum on a rotary evaporator, and the crude product is purified by flash chromatography on silica gel using chlorofomi/ethanol as eluant.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05760021
Source datasetuspto-grants-1998_06
ORD IDord-e6981417b37841df94d9d307ffb80013
Source noteuspto-grants-1998_06