HCID 19084743, compound → HCID 19084778, compound

Participants

Reaction Steps

A mixture of 1 g of 1-methyl-2-(2-carboxy-2-hydroxy-2-phosphonoethyl)pyridinium iodide and 0.5 g of palladium on charcoal catalyst in 50 ml of distilled water is hydrogenated on a Parr apparatus at 40 PSI for about 2 days. The catalyst is removed by filtration, and the filtrate is evaporated to dryness. The residue is triturated with ethanol to give a solid which is collected by filtration. It is recrystallized from water/ethanol to afford 2-hydroxy-3-(1-methyl-2-piperidinyl)-2-phosphonopropanoic acid.

Provenance & Evidence