2-Hydroxy-2-phosphono-3-(pyridin-2-yl)propanoic acid → 2-Hydroxy-3-(2-piperidinyl)-2-phosphonopropanoic acid

Participants

Reaction Steps

A mixture of 1 g of 2-hydroxy-2-phosphono-3-(2-pyridinyl)propanoic acid and 0.5 g of palladium on charcoal catalyst in 50 ml of distilled water is hydrogenated on a Parr apparatus at 40 PSI for about 2 days. The catalyst is removed by filtration, and the filtrate is concentrated to a few mls. Ethanol is added slowly to precipitate a solid, which is recrystallized from water/ethanol to afford 2-hydroxy-3-(2-piperidinyl)-2-phosphonopropanoic acid.

Provenance & Evidence