Thionyl Chloride → HCID 19085382, compound

Participants

Reaction Steps

To a solution of 12.9 g of N-[1-(2-bromophenyl)-3-hydroxypropyl]-2,6-difluorobenzamide in 80 ml of benzene under refluxing, was added dropwise 5.0 g of thionyl chloride for 10 minutes and stirring continued for an additional 30 minutes. Aftercooling, the precipitated solid was filtered, washed several times with n-hexane and dried to afford 13.0 g of N-[1-(2-bromophenyl)-3-chloropropyl]-2,6-difluorobenzamide. m.p. 183°-185° C.

Provenance & Evidence