HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(2-Dimethylaminoethyl)-1-[2-(4-fluorophenoxy)ethyl]piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2-Bromoethoxy)-4-fluorobenzene | HCID 2064171 | — |
| Reactant | N,N-Dimethyl-2-(piperidin-4-yl)ethanamine dihydrochloride | HCID 19085438 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Dimethylaminoethyl)-1-[2-(4-fluorophenoxy)ethyl]piperidine dihydrochloride | HCID 19085443 | — |
Reaction Steps
In a similar manner to Example 16, a mixture of 4-(2-dimethylaminoethyl)piperidine dihydrochloride (5.5 g), 2-bromoethyl 4-fluorophenyl ether (5.26 g), triethylamine (13.4 ml) and DMF (50 ml) was heated on a steam bath for 16 hours to give 4-(2-dimethylaminoethyl)-1-[2-(4-fluorophenoxy)ethyl]piperidine dihydrochloride, m.p. 260°-262° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760035 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-378951a05841445b86bbf833c2bc3f3d |
| Source note | uspto-grants-1998_06 |