Citric Acid → HCID 67662890, compound

Participants

Reaction Steps

A mixture of 3-chloromethyl-1-(2-phenoxyethyl)piperidine (2.8 g) and piperidine (15 ml) was heated on a steam bath for 24 hours. The excess piperidine was removed under reduced pressure and the residue purified by azeotropic distillation with toluene. The residue was dissolved in ether/water and then basified to pH 14. The mixture was extracted with ether and the combined ether extracts yielded an oil which was dissolved in ether and acidified with ethereal citric acid to give a solid which was collected by filtration to give 1-(2-phenoxyethyl)-3-(piperidin-1-ylmethyl)piperidine dicitrate, m.p. 88°-89° C. (with decomposition).

Provenance & Evidence