HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Phenyl-4-[[1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy]methyl]piperidine-1-carboxylic acid tert-butyl ester | HCID 10554613 | — |
| Product | 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride | HCID 19084700 | — |
Reaction Steps
The compound of step (d) above was dissolved in methanolic hydrogen chloride for 2 hours then concentrated and triturated with diethyl ether and filtered to give the title compound as a white solid, m.p. 198°-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760018 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-915c52e36b3047069a931608ea87fabd |
| Source note | uspto-grants-1998_06 |