Bromomethylcyclopropane → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-cyclopropylmethoxyethoxy) methyl)piperidine Hydrochloride

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Reaction Steps

This was prepared in a similar manner to Example 2 using the compound of Example 1 (d) and cyclopropyl methyl bromide. 1H NMR (360MHz, d6 -DMSO) δ 7.91 (1H, s), 7.66 (2H, s), 7.35-7.19 (5H, m), 4.58 (1H, t, J=4.7 Hz), 3.50-3.06 (6H, m), 2.76-2.61 (2H, m), 2.33-2.17 (2H, m), 2.08-1.94 (2H, m), 0.84-0.77 (1H, m), 0.36-0.30 (2H, m), 0.01-0.06 (2H, m). MS (Cl+) 502 (M+H)+.

Provenance & Evidence