Water → HCID 10745467, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-[1(-tert-butoxycarbonyl4-phenylpiperidin4-yl)methoxy]-2-(3,5-bis(trifluoromethyl)phenyl)acetate (11 g, 0.019 mol) in methanol (100 ml) at 0° C. was added potassium hydroxide (3.2 g, 5.7 mmol), followed by water (3 ml). The homogeneous solution was stirred at 0° C. for 1 hour. The methanol was removed in vacuo and pH4 buffer (100 ml) added to the residue. The product was extracted into diethyl ether (2×100 ml), the combined ethereal solutions dried (MgSO4), filtered and evaporated in vacuo. The resulting white foam was used without further purification.

Provenance & Evidence