10,11-Dihydro-10-(4-nitrobenzoyl)dibenz[b,f][1,4]thiazepine → 10,11-Dihydro-10-(4-aminobenzoyl)dibenz[b,f][1,4]thiazepine

HRID 962519노트

반응식

HRID 962519 반응식
[N+:1]([C:4]1[CH:26]=[CH:25][C:7]([C:8]([N:10]2[CH2:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[S:13][C:12]3[CH:21]=[CH:22][CH:23]=[CH:24][C:11]2=3)=[O:9])=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO>[NH2:1][C:4]1[CH:26]=[CH:25][C:7]([C:8]([N:10]2[CH2:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[S:13][C:12]3[CH:21]=[CH:22][CH:23]=[CH:24][C:11]2=3)=[O:9])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 5457007210,11-Dihydro-10-(4-nitrobenzoyl)dibenz[b,f][1,4]thiazepineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 5423000210,11-Dihydro-10-(4-aminobenzoyl)dibenz[b,f][1,4]thiazepine수율 89.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2.2 g of 10,11-dihydro-10-(4-nitrobenzoyl)dibenz[b,f] [1,4]thiazepine in 150 ml of methanol is shaken in a Parr hydrogenator under 50 pounds per square inch of hydrogen for 72 hours. The mixture is filtered through diatomaceous earth and the filtrate evaporated in vacuo. The residue is recrystallized from chloroform-hexane to give 1.8 g of crystals, m.p. 52°-55° C.

후처리

  1. filtrationThe mixture is filtered through diatomaceous earth
  2. customthe filtrate evaporated in vacuo
  3. customThe residue is recrystallized from chloroform-hexane

출처 및 근거

ORD 기록
ord-b0e3055d829a4211a97d024e2c1bdbd1
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760031

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