Water → HCID 10568805, compound

Participants

Reaction Steps

A mixture of 8-methoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one (1.5 g, 6.5 mmol), potassium carbonate (0.50 g, 4.7 mmol), and (2-bromethyl)benzene (1.0 mL, 1.4 g, 7.3 mmol) in 10 mL of N,N-dimethylformamide is heated at 900 for 18 hours. The cooled reaction mixture is added to 300 mL of water and 150 mL of ethyl ether. The insoluble material is filtered and washed with fresh ethyl ether. Recrystallization of the solid from aqueous 2-propanol gives 0.60 g (27%) of product; mp 135°-136° C.

Provenance & Evidence