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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 962684Generated: October 26, 2026

4-[Amino(phenyl)methyl]phenol → N-(4-Hydroxybenzhydryl)-3-cyanoandrosta-3,5-diene-17beta-carboxamide

https://huagongshe.com/reaction/962684

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[Amino(phenyl)methyl]phenolHCID 4962203—
ReactantS-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylateHCID 15380265—
ProductN-(4-Hydroxybenzhydryl)-3-cyanoandrosta-3,5-diene-17beta-carboxamideHCID 1538027083%

Reaction Steps

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 4-hydroxybenzhydrylamine (prepared as described in Preparation 13) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 83%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05760025
Source datasetuspto-grants-1998_06
ORD IDord-47d461dc1bc54a36aeae9108f0788e17
Source noteuspto-grants-1998_06