Methyl 4-fluorobenzoate → 1-(4-Fluorophenyl)-1-methylethylamine

HRID 962704Notes

Reaction equation

HRID 962704 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[F:13]C1C=CC(C(OC)=O)=CC=1>>[F:13][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 67878Methyl 4-fluorobenzoateHCID 110082782-(4-Methoxyphenyl)propan-2-amine

Product 1

HCID 130256651-(4-Fluorophenyl)-1-methylethylamineYield 20%

Procedure

Following a procedure similar to that described in Preparation 10a, but using methyl 4-fluorobenzoate as a starting material, in a relative amount similar to that used in that Preparation, the title compound was obtained in a yield of 20%.

Workup

  1. customin a relative amount similar to that used in that Preparation

Sources & evidence

ORD record
ord-b4fb3f34f5b545f692263a19855bc2ad
Source dataset
uspto-grants-1998_06
Patent number
US05760025

Reaction notes

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