1,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-one → HCID 19085890, compound

HRID 962722Notes

Reaction equation

HRID 962722 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][C:8]2=[O:17])[CH2:3][CH2:2]1.Br[CH2:19][CH2:20][CH2:21][CH2:22][N:23]1[C:27](=[O:28])[C:26]2[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=2[S:24]1(=[O:34])=[O:33]>>[O:33]=[S:24]1(=[O:34])[C:25]2[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=2[C:27](=[O:28])[N:23]1[CH2:22][CH2:21][CH2:20][CH2:19][N:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][C:8]2=[O:17])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 107817741,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-oneHCID 19085848HCID 19085848, compound

Product 1

HCID 19085890HCID 19085890, compound

Procedure

From the hydrochloride salt of 1-(4-piperidyl)-2(1H)-quinolinone was prepared according to H. Ogawa et. al. J. Med. Chem. 1993, 36, 2011-2017, and 2-(4-bromobutyl)-1,1-dioxido-1,2-benzothiazol-3(2H)-one using the procedure described for Example 15, Step 5 there was obtained a white solid: 1H NMR (300 MHz, CDCl3) 8.08 (d, J=6.73 Hz, 1H), 7.90 (m, 3H), 7.7 (d, J=9.5 Hz, 1H), 7.6 (d, J=9.2 Hz, 1H), 7.56 (d, J=7.62 Hz, 1H), 7.26 (m, 2H), 6.71 (d, J=9.47 Hz, 1H), 3.85 (br m, 3H), 3.45 (br m, 1H), 3.25 (br m, 3H), 3.14 (br m, 6H), 1.95 (br s, 4H).

Workup

  1. customwas obtained a white solid

Sources & evidence

ORD record
ord-328c707d74b24e06a226e9b31c4ecae5
Source dataset
uspto-grants-1998_06
Patent number
US05760054

Reaction notes

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