1,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-one → HCID 19085832, compound

HRID 962727Notes

Reaction equation

HRID 962727 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:18])[C:5]2[O:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:6]=2[CH:17]=1.Br[CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=2[S:25]1(=[O:35])=[O:34]>>[O:34]=[S:25]1(=[O:35])[C:26]2[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=2[C:28](=[O:29])[N:24]1[CH2:23][CH2:22][CH2:21][CH2:20][N:14]1[CH2:15][CH2:16][CH:11]([N:7]2[C:6]3[CH:17]=[C:2]([CH3:1])[CH:3]=[C:4]([CH3:18])[C:5]=3[O:9][C:8]2=[O:10])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 107817741,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-oneHCID 19085895HCID 19085895, compound

Product 1

HCID 19085832HCID 19085832, compound

Procedure

From the hydrochloride salt of 4-(5,7-dimethyl-2-oxo-3-benzoxazolinyl)-piperidine and 2-(4-bromobutyl)-1,1-dioxido-1,2-benzothiazol-3(2H)-one using the procedure described for Example 15, Step 5 there was obtained a white solid: 1H NMR (300 MHz, CDCl3) 8.08 (d, J=7.27 Hz, 1H), 7.90 (m, 3H), 7.65 (br m, 1H), 6.752 (s, 1H), 4.55 (br m, 1H), 3.85 (br t, 2H), 3.70 (br m, 2H), 3.32 (br m, 2H), 3.10 (br m, 2H), 2.87 (br m, 2H), 2.413 (s, 3H), 2.318 (s, 3H), 2.06 (br m, 6H).

Workup

  1. customwas obtained a white solid

Sources & evidence

ORD record
ord-562f8e3c63cd4db38fed98cfd00e2f6b
Source dataset
uspto-grants-1998_06
Patent number
US05760054

Reaction notes

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