HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(4'-Ketopiperidinyl)butylphthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Piperonylamine | HCID 2723901 | — |
| Reactant | Bromobutylphthalimide | HCID 21960043 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-(4'-Ketopiperidinyl)butylphthalimide | HCID 19085840 | 21.8% |
Reaction Steps
A solution of 4-piperidone hydrochloride hydrate (2 gram, 13 mmol), bromobutylphthalimide (3.67 gram, 13 mmol) and triethylamine (3.4 ml, 26 mmol) in Chloroform (25 ml) was refluxed overnight. The reaction mixture was washed with sat. NaHCO3 and was dried over Na2SO4. Purification using flash chromatography gave 4-(4'-ketopiperidinyl)butylphthalimide (0.85 gram).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05760054 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-0bfb102f7b9d429b861ae4a0bdcebcee |
| Source note | uspto-grants-1998_06 |