3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-one → 1,1-Dioxido-2-(4-(4-(2-oxo-3-benzoxazolinyl)-piperidin-1-yl)-butyl)-5-ethyl-1,2-benzothiazol-3(2H)-one

Participants

Reaction Steps

From 4-(2-oxo-3-benzoxazolinyl)-piperidine and 2-(4-hydroxybutyl)-1,1-dioxido-5-ethyl-1,2-benzothiazol-3(2H)-one using the procedure described for Example 66, Steps 4-6 there was obtained a white solid: mp 165°-168 ° C. 1H NMR (400 MHz, CDCl3) 7.9 (s, 1H), 7.8 (m, 1H), 7.66 (m, 1H), 7.3 (m, 1H), 7.2-7.05 (m, 3H), 4.2 (m, 1H), 3.8 (m, 2H), 3.1 (m, 2H), 2.82 (m, 2H), 2.4 (m, 2H), 2.1 (m, 2H), 2.0-1.8 (br m, 4H), 1.8-1.6 (br m, 4H), 1.3 (t, 3H) Analysis calculated for C25H30N3O6S·HCl·1.4 H2O C: 55.66, H: 6.06, N: 7.01 found C: 55.82, H: 5.81, N: 6.91.

Provenance & Evidence