Potassium Hydroxide → HCID 23700461, compound

HRID 962759Notes

Reaction equation

HRID 962759 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]([C:46]1[CH:51]=[CH:50][C:49]([CH3:52])=[CH:48][CH:47]=1)[CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][N:35]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=2[O:44][CH3:45])[CH2:34][CH2:33]1)[C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])[CH:9]=1)=[O:7].[OH-].[K+:54]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]([C:46]1[CH:47]=[CH:48][C:49]([CH3:52])=[CH:50][CH:51]=1)[CH2:30][CH2:31][N:32]1[CH2:33][CH2:34][N:35]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=2[O:44][CH3:45])[CH2:36][CH2:37]1)[C:6]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:17][CH2:18][CH2:19][C:20]([O-:22])=[O:21])[CH:9]=1)=[O:7].[K+:54]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19085586HCID 19085586, compound

Product 1

HCID 23700461HCID 23700461, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 4-{3-{3-methoxy-4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl} indol-1-yl}butanoate (2.00 g) was dissolved in ethanol (20 ml). Potassium hydroxide (0.64 g) was added to the resultant solution and stirred overnight at room temperature. After removing the solvent, the residue was purified using an HP-20 column, obtaining 1.34 g of potassium 4-{3-{3-methoxy-4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}indol-1-yl}butanoate as amorphous powder.

Workup

  1. customAfter removing the solvent
  2. customthe residue was purified

Sources & evidence

ORD record
ord-f9ea3c2c288c4e67a59b1a7bfe7f56f9
Source dataset
uspto-grants-1998_06
Patent number
US05760040

Reaction notes

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