Carbon tetrabromide → HCID 19085566, compound

Participants

Reaction Steps

Ethyl 4-{3-[4-(1-phenyl-3-hydroxypropoxy) benzoyl]indol-1-yl}butanoate (4.00 g) obtained in Step 1 was dissolved in methylene chloride (40 ml). Triphenylphosphine (3.24 g) and carbon tetrabromide (3.24 g) were added to the resultant solution while cooling on ice bath and stirred for 30 minutes at room temperature. Saturated sodium bicarbonate solution was added to the reaction mixture to separate an organic layer. The organic layer was washed with brine and then dried. The solvent was distilled off. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1), obtaining 3.97 g of ethyl 4-{3-[4-(3-bromo-1-phenylpropoxy)benzoyl]indol-1-yl}butanoate as colorless oily substance.

Provenance & Evidence