Hydrochloric Acid → HCID 19085567, compound

Participants

Reaction Steps

3-(3-Chloropropoxy)-4-benzyloxybenzoyl chloride, which was prepared using 4-benzyloxy-3-(3-chloropropoxy)benzoic acid (2.53 g) and oxalyl chloride (1 ml), was dissolved in dichloroethane (20 ml). Aluminum chloride (2.63 g) was added to the resultant solution while cooling on ice bath, stirred for 5 minutes at room temperature, and then cooled again on ice bath. 1-(Phenylsulfonyl)indole (1.69 g) in dichloroethane (10 ml) was added dropwise to the resultant mixture and stirred for 2.5 hours at room temperature. The reaction mixture was poured into 1N HCl and extracted with ethyl acetate. The resultant extract was sequentially washed with saturated sodium bicarbonate solution and brine and then dried. The solvent was distilled off. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1), obtaining 0.76 g of 3-[4-hydroxy-3-(3-chloropropoxy)benzoyl]-1-(phenylsulfonyl) indole as a yellow oily substance.

Provenance & Evidence