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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 962803Generated: October 26, 2026

4-(Trifluoromethyl)aniline → 4-(4-Trifluoromethylphenylaminosulfonyl)-5-methylisoxazole

https://huagongshe.com/reaction/962803

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)anilineHCID 9964—
Reactant5-Methyl-1,2-oxazole-4-sulfonyl chlorideHCID 2776141—
Reactant2-(4-Trifluoromethylphenylaminosulfonyl)1-ethoxypropeneHCID 56982552—
Product4-(4-Trifluoromethylphenylaminosulfonyl)-5-methylisoxazoleHCID 57089194—

Reaction Steps

AA16 was prepared starting from 2-(4-trifluoromethylphenylaminosulfonyl)1-ethoxypropene under the same conditions as described for AA11. Alternatively, AA16 was prepared from 4-trifluoromethylaniline and 4-chlorosulfonyl-5-methylisoxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05760066
Source datasetuspto-grants-1998_06
ORD IDord-dc4e9641eb91427b9dcb45310c5bab47
Source noteuspto-grants-1998_06