Benzamidine, hydrochloride → HCID 135453348, compound

Participants

Reaction Steps

4.9 g (10.86 mmol) of benzamidine hydrochloride (38% in methanol) and then a solution of 1.95 g (10.86 mmol) of sodium methoxide (30% in methanol) are added to a suspension of 2.83 g (10 mmol) of 7-methoxy-2-(4-methoxyphenyl)-4H-1,3-benzoxazin-4-one in 48 ml of methanol. The mixture is heated to boiling and diluted with 38 ml of methanol. After refluxing (30 minutes), the precipitate is filtered off with suction while hot and washed twice with 10 ml of methanol each time. Recrystallization from chloroform/petroleum ether gives 3.74 g (97% of theory) of the product of the formula ##STR25## M.p.: 171°-172° C. UV spectrum (2.25·10-5 mol in chloroform) λmax /εmax =297/34920 325/shoulder

Provenance & Evidence