Trifluoroacetic acid → HCID 19610515, compound

Participants

Reaction Steps

To a stirred suspension of the product of step (a) (2.9 g) in a mixture of dichloromethane (20 ml) and anisole (2 ml) at 0°-5° C. was added trifluoroacetic acid (27 ml). The resultant solution was stirred at low temperature for 20 minutes and then at ambient temperature for 2.5 hours. The reaction mixture was evaporated and the residue was triturated with dry ether. The solid was collected and washed with ether to give methyl 4-(3-methylcarbazoyl)-phenoxyacetate trifluoroacetate salt (2.9 g), as a white solid; m.p. 121°-123° C.; NMR Spectrum (DMSO--d6) 2.80 (3H, s), 3.70 (3H, s), 4.93 (2H, s), 7.10 (2H, d), 7.85 (2H, d), 10.80-11.70 (1H, br s); Mass Spectrum m/Z 239 (M+H)+.

Provenance & Evidence