HCID 67626847, compound → HCID 18913499, compound

HRID 962910Notes

Reaction equation

HRID 962910 reaction equation
[C:1]1([C:7]2[S:8][C:9]([CH2:12][CH:13]=[CH:14][OH:15])=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:1]1([C:7]2[S:8][C:9]([CH2:12][CH2:13][CH2:14][OH:15])=[CH:10][N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 67626847HCID 67626847, compound

Product 1

HCID 18913499HCID 18913499, compoundYield 78.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 960 mg of the product of Stage F in 10 ml of methanol was hydrogenated for 12 hours at one atmosphere, then for 9 hours under 1.4 atmospheres in the presence of 150 mg of palladium on charcoal. After filtration, evaporation to dryness under reduced pressure was carried out. The residue was chromatographed on silica (eluant: ethyl acetate-cyclohexane (4-6)) to obtain 759 mg of the desired product.

Workup

  1. filtrationAfter filtration, evaporation to dryness under reduced pressure
  2. customThe residue was chromatographed on silica (eluant: ethyl acetate-cyclohexane (4-6))

Sources & evidence

ORD record
ord-ee67f895f4394c5faba56fa1d4635726
Source dataset
uspto-grants-1998_06
Patent number
US05760233

Reaction notes

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