Acetonitrile → HCID 131720682, compound

Participants

Reaction Steps

6.64 g (40 mmole) of 3-phenyl-D-lactic acid and 3.7 g (44 mmole) of dihydropyran are reacted in acetonitrile according to the method of Obrecht and Heimgartner [Helv. Chim. Acta 67, 526 (1984)]. The reaction mixture is evaporated at 20-25 millibar from a water bath at about 40° C. The residue is dissolved in 20 ml of dichloromethane, washed with water, dried over sodium sulfate and repeatedly evaporated. The obtained O-tetrahydropyranyl-3-phenyl-D-lactic acid is dissolved in diethyl ether and converted into cyclohexylammonium salt. The crystals are filtered off, washed with diethyl ether and dried at reduced pressure.

Provenance & Evidence