Cyclohexylammonium Ion → HCID 131720684, compound

Participants

Reaction Steps

8.74 g (25 mmole) of O-tetrahydropyranyl-3-phenyl-D-lactic acid cyclohexylammonium salt (Example 5, Step A) is dissolved in 30 ml of 1M potassium hydrogen sulfate and 50 ml of dichloromethane. The dichloromethane layer is washed with water, dried over sodium sulfate and evaporated at 20-25 millibar from a water bath at about 40° C. The obtained O-tetrahydropyranyl-3-phenyl-D-lactic acid and 4.15 g (25 mmole) of L-proline methyl ester hydrochloride are condensed by the method of Obrecht and Heimgartner [Helv. Chim. Acta 67, 526 (1984)], the O-tetrahydropyranyl-3-phenyl-D-lactyl-L-proline methyl ester formed is saponified and the resulting O-tetrahydropyranyl-3-phenyl-D-lactyl-L-proline is converted in diethyl ether solution to the crystalline cyclohexylammonium salt.

Provenance & Evidence