(Dimethyl sulfide)trihydroboron → HCID 178456098, compound

Participants

Reaction Steps

2.5 ml (25 mmol) of borane-dimethyl sulphide adduct were added dropwise at 200C to a solution of 10.0 g (41.3 mmol) of propionylferrocene and 2.5 ml (2.5 mmol, 0.06 eq) of catalyst (S)-III (R6 =CH3) in 30 ml of tetrahydrofuran over a period of 30 minutes. After 1 hour at 20°-25° C., the reaction mixture was poured while stirring vigorously onto about 200 ml of ice/water and stirred for 0.5 hours. The aqueous phase was subsequently extracted three times with 200 ml each time of tert-butyl methyl ether, the combined organic phases were dried over magnesium sulphate and evaporated in a high vacuum. This gave 10.7 g (106%) of the crude title compound. This crude product can be used without further purification for the further reactions.

Provenance & Evidence