Pyridine → HCID 178476620, compound

HRID 962996Notes

Reaction equation

HRID 962996 reaction equation
N1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:7]([O:10][C:11](=[O:13])[CH3:12])(=O)[CH3:8].[OH:14][C@H:15]([C-:17]1[CH:21]=[CH:20][CH:19]=[CH:18]1)[CH3:16].[C-:22]1([C@@H:27]([OH:29])C)C=CC=C1.[Fe+2:30]>O>[C:11]([O:10][C@H:7]([C-:2]1[CH:6]=[CH:5][CH:4]=[CH:3]1)[CH3:8])(=[O:13])[CH3:12].[C-:17]1([C@@H:15]([O:14][C:27](=[O:29])[CH3:22])[CH3:16])[CH:21]=[CH:20][CH:19]=[CH:18]1.[Fe+2:30]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 178462226HCID 178462226, compound

Product 1

HCID 178476620HCID 178476620, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

4.0 ml of pyridine and 4.0 ml of acetic anhydride were added to 4.00 g (14.6 mmol) of (S,S)-1,1'-bis(1-hydroxyethyl)ferrocene and the resulting solution was stirred overnight at 25° C. After hydrolysis of the excess anhydride using 100 ml of water, the hydrolysis mixture was extracted twice with 200 ml each time of diethyl ether and the combined organic extracts were dried over magnesium sulphate. The solvent was taken off and the residue was dried to constant weight in a high vacuum.

Workup

  1. extractionthe hydrolysis mixture was extracted twice with 200 ml each time of diethyl ether
  2. dry with materialthe combined organic extracts were dried over magnesium sulphate
  3. customthe residue was dried to constant weight in a high vacuum

Sources & evidence

ORD record
ord-07afecf7897c464cb72dbf5d0feff7d5
Source dataset
uspto-grants-1998_06
Patent number
US05760264

Reaction notes

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