3,3,3-Trifluoro-1-phenylpropan-1-amine → 2-[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-1,2,4-triazol-1-yl]-N-(3,3,3-trifluoro-1-phenylpropyl)acetamide

HRID 96301Notes

Reaction equation

HRID 96301 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]([CH2:21][C:22](=[O:23])[NH:24][CH:25]([c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]3[CH3:32])[CH2:33][CH2:34][OH:35])[c:11](=[O:20])[n:12]2[CH2:13][CH:14]([C:15]([F:16])([F:17])[F:18])[OH:19])[cH:6][cH:7]1.[F:36][C:37]([CH2:38][CH:39]([NH2:40])[c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)([F:47])[F:48]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]([CH2:21][C:22](=[O:23])[NH:40][CH:39]([CH2:38][C:37]([F:36])([F:47])[F:48])[c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)[c:11](=[O:20])[n:12]2[CH2:13][CH:14]([C:15]([F:16])([F:17])[F:18])[OH:19])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 178957523,3,3-Trifluoro-1-phenylpropan-1-amineHCID 723194902-[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-1,2,4-triazol-1-yl]-N-[3-hydroxy-1-(2-methylphenyl)propyl]acetamide

Product 1

HCID 723194802-[3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-1,2,4-triazol-1-yl]-N-(3,3,3-trifluoro-1-phenylpropyl)acetamide

Sources & evidence

ORD record
ord-2588e1670e67441083886f3588dcfbec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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