Benzoyl chloride → HCID 67727839, compound

Participants

Reaction Steps

3-Aminomethyl-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazole di-p-toluenesulfonate (2.0 g) was dissolved in dimethylformamide (20 ml), and benzoyl chloride (0.42 ml) and triethylamine (1.5 ml) were added under ice-cooling. The mixture was stirred at room temperature for 8 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with an aqueous citric acid solution and saturated brine, and dried over magnesium sulfate. After the solvent was evaporated, the residue was recrystallized from ethyl acetate to give 0.3 g of N-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-3-ylmethyl)benzamide.

Provenance & Evidence