Sodium Hydroxide → 2-(4-(3-(2-Chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetic acid

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate (2.0 g) and a solution of sodium hydroxide (0.39 g) in ethanol were added to ethanol (20 ml), and the mixture was stirred at 50° C. for 20 minutes. The solvent was evaporated, and the residue was dissolved in water. Toluene was added to the solution for washing. The aqueous layer was taken out, and 2M hydrochloric acid was added to adjust the solution to pH 2. The solution was extracted with chloroform. The extract was dried over magnesium sulfate, and the solvent was evaporated. The residue was recrystallized from ethyl acetate to give 0.45 g of 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetic acid.

Provenance & Evidence