反应详情

温度

50 °C

Methanol (60 ml) and a 2M aqueous sodium hydroxide solution (7.0 ml) were added to ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate (4.0 g), and the mixture was stirred at 50° C. for 30 minutes and at room temperature for 4 hours. Methanol was evaporated, and water and ethyl acetate were added. The aqueous layer was taken out, and citric acid was added to adjust the solution to pH 3. The solution was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated, and the residue was recrystallized from ethyl acetate to give 2.6 g of 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetic acid.

1. customMethanol was evaporated
2. additionwater and ethyl acetate were added
3. additioncitric acid was added
4. extractionThe solution was extracted with ethyl acetate
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over magnesium sulfate
7. customThe solvent was evaporated
8. customthe residue was recrystallized from ethyl acetate