Hydrochloric Acid → HCID 19085375, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Chlorophenyl)-2-ethyl-9-trifluoromethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine (1.0 g) was added to 10% hydrochloric acid (20 ml), and the mixture was stirred at 70° C. overnight. Then, sodium hydrogencarbonate was added to the reaction mixture to make the mixture alkaline. Chloroform (20 ml) and 3,4-dichlorobenzoyl chloride (0.58 g) were added, and the mixture was stirred under ice-cooling for 1 hour. Then, the organic layer was washed with an aqueous citric acid solution, a saturated aqueous sodium hydrogencarbonate solution and saturated brine, and dried over magnesium sulfate. The solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give 0.60 g of N-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-trifluoromethyl[1,2,4]triazol-3-ylmethyl)-3,4-dichlorobenzamide.

Provenance & Evidence