Sodium Hydroxide → 2-(4-(3-(2-Chlorobenzoyl)-5-ethylthiophen-2-yl)-5-trifluoromethyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetic acid

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Reaction Steps

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-trifluoromethyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetate (1.5 g) and a 2M aqueous sodium hydroxide solution (1.25 ml) were added to methanol (20 ml), and the mixture was stirred at room temperature for 30 minutes. Then, the solvent was evaporated and the residue was dissolved in water. Ethyl acetate was added to the solution for washing. The aqueous layer was taken out, and citric acid was added to adjust the solution to pH 3. The solution was extracted with ethyl acetate and the extract was dried over magnesium sulfate. The solvent was evaporated, and the residue was crystallized from ethyl acetate to give 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-trifluoromethyl[1,2,4]triazol-3-ylmethylcarbamoyl)indole-1-acetic acid.

Provenance & Evidence