反应详情

温度

80 °C

9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine (1.0 g) was added to 2M sulfuric acid (26.5 ml), and the mixture was stirred at 80° C. overnight. Sodium hydrogencarbonate was added to the reaction mixture to make the mixture alkaline. Chloroform and indole-2-carbonyl chloride were added, and the mixture was stirred at room temperature for 1.5 hours. The obtained crystals were filtered and washed with ethyl acetate to give 0.196 g of N-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethyl)indole-2-carboxamide.

1. stirringthe mixture was stirred at room temperature for 1.5 hours
2. filtrationThe obtained crystals were filtered
3. washwashed with ethyl acetate