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HRID 963055作成日：2026年10月25日
Sulfuric Acid → Ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate
https://huagongshe.com/reaction/963055
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-Ethoxycarbonylmethylindole-2-carbonyl chloride | HCID 19085163 | — |
| 反応物 | 9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine | HCID 67727685 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate | HCID 67727711 | — |
反応手順
9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine is added to 2M sulfuric acid, and the mixture is stirred at 80° C. overnight. Sodium hydrogencarbonate is added to the reaction mixture to make the mixture alkaline. Chloroform and 1-ethoxycarbonylmethylindole-2-carbonyl chloride are added, and the mixture is stirred at room temperature for 2 hours to give ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05760032 |
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| 出典データセット | uspto-grants-1998_06 |
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| ORD ID | ord-af9f8ca814e94e85a28d22b03ef4b8ea |
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| 出典メモ | uspto-grants-1998_06 |
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