Sodium Hydroxide → HCID 19085206, compound

HRID 963059Notes

Reaction equation

[Cl:1][C:2]1[CH:42]=[CH:41][CH:40]=[CH:39][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH2:18][NH:19][C:20]([C:22]2[N:23]([CH2:31][C:32]([O:34]CC)=[O:33])[C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])=[N:16][N:15]=[C:14]1[CH2:37][OH:38])=[O:5].[OH-].[Na+]>>[Cl:1][C:2]1[CH:42]=[CH:41][CH:40]=[CH:39][C:3]=1[C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[N:13]1[C:17]([CH2:18][NH:19][C:20]([C:22]2[N:23]([CH2:31][C:32]([OH:34])=[O:33])[C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])=[N:16][N:15]=[C:14]1[CH2:37][OH:38])=[O:5]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 22439206HCID 22439206, compound

Product 1

HCID 19085206HCID 19085206, compound

Procedure

Ethyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-3-hydroxymethyl[1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate is subjected to alkali hydrolysis using a 2M aqueous sodium hydroxide solution to give 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-3-hydroxymethyl[1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetic acid.

Sources & evidence

ORD record: ord-9a75868b364e4575ab03d563910e7bd5
Source dataset: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05760032

Reaction notes

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