反应详情

Ethyl 5-amino-4-(2-chlorobenzoyl)thiophene-2-carboxylate (280 g) and chloroacetyl chloride (218 ml) were added to chloroform (4 l), and the mixture was refluxed under heating for 2.5 hours. Water was added thereto. The organic layer was taken out, and dried over magnesium sulfate. The solvent was evaporated. Then, diisopropyl ether was added, and the resulting crystals were collected by filtration and washed with diisopropyl ether to give 325 g of ethyl 5-(2-chloroacetylamino)-4-(2-chlorobenzoyl)thiophene-2-carboxylate.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 2.5 hours
3. dry with materialdried over magnesium sulfate
4. customThe solvent was evaporated
5. additionThen, diisopropyl ether was added
6. filtrationthe resulting crystals were collected by filtration
7. washwashed with diisopropyl ether