Sodium Hydroxide → HCID 19085310, compound

Participants

Reaction Steps

Methanol (13 ml) and a 2M sodium hydroxide aqueous solution (2.5 ml) were added to methyl 3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)benzoate (1.3 g), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was evaporated, and the residue was partitioned between water and ethyl acetate. The aqueous layer was taken out, and citric acid was added to adjust the aqueous solution to pH 3. The solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated, and the residue was recrystallized from a mixed solvent of ethyl acetate and diisopropyl ether to give 1.05 g of 3-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)-5-methyl[1,2,4]triazol-3-ylmethylcarbamoyl)benzoic acid.

Provenance & Evidence