2-Aminothiazole → HCID 67658626, compound

Participants

Reaction Conditions

Reaction Steps

5 g (50 mmol) of 2-aminothiazole was dissolved in 15 ml of dimethylformamide, and 8.8 g (62.4 mmol) of 1-bromo-3-fluoropropane was added at room temperature. The reaction mixture was heated with stirring at 80° C. for 7.5 hours and then allowed to cool to room temperature. After addition of 300 ml of ethyl acetate, the reaction mixture was stirred at room temperature for 10 minutes. The resulting oily substance was separated from the ethyl acetate solution by decantation, and the same operation was repeated twice. The oily substance was crystallized by adding ethyl acetate and a small amount of methanol and filtered off to obtain 5.5 g of 2-imino-3-(3-fluoropropyl)thiazoline hydrobromide (4: Z=Br). Melting point 153°-155° C.

Provenance & Evidence