Potassium Hydroxide → HCID 11051953, compound

Participants

Reaction Steps

Then, 1.21 g (5 mmol) of 2-imino-3-(3-fluoropropyl)thiazoline hydrobromide (4: Z=Br) was stirred with 0.33 g (5 mmol) of 85% potassium hydroxide in 20 ml of methanol at room temperature for 1 hour. After the methanol was distilled off under reduced pressure, 20 ml of chloroform was added to the residue, and precipitated insolubles were filtered out. The chloroform in the filtrate was distilled off under reduced pressure to obtain 0.8 g of 2-imino-3-(3-fluoropropyl)thiazoline (3) as an oily substance. The chemical shifts by NMR were as follows. (60 MHz) δ(ppm, CDCl3): 1.6-2.7(2H,m), 3.84(2H,t,J=6.8 Hz), 4.50(2H,dt,J=47.0 Hz,5.6 Hz), 5.74(1H,d,J=4.7 Hz), 6.40(1H,d,J=4.7 Hz), 5.5-6.8(1H,br)

Provenance & Evidence