HCID 178448756, compound → HCID 178448755, compound

Participants

Reaction Steps

Into 40 ml of an absolute methanol solution of 5.3 g of 2-tert-butyl-4-hydroxy-5-nitropyridazin-3-(2H)-one, 0.5 g of palladium-carbon (containing 5% of Pd) was added in a few times at room temperature with stirring. Then, catalytic reduction was carried out overnight under hydrogen gas pressure. After completion of the reaction, the palladium-carbon was separated by filtration with celite and washed a few times with absolute methanol. The methanol was combined with the filtrate, followed by distillation under reduced pressure to obtain 4.4 g of powdery 5-amino-2-tert-butyl-4-hydroxypyridazin-3-(2H)-one.

Provenance & Evidence