Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 963209Generated: October 25, 2026

Citric Acid → Guaifenesin

https://huagongshe.com/reaction/963209

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCitric AcidHCID 311—
ReactantD-(-)-FructoseHCID 5984—
ReactantTrisodium citrateHCID 6224—
ProductGuaifenesinHCID 3516—

Reaction Steps

The maltitol was similarly admixed with Phase F to form Phase G to which the ammonium glycyrrhizinate was added with another about 5 minutes mixing time being used. The flavors and colorants were then admixed, with a mixing time of about 5 minutes, followed by addition of a sufficient amount of liquid fructose to make the desired volume and mixing to homogeneity. The pH value was thereafter adjusted to be between 4 and 5 using a citric acid or sodium citrate solution. This composition provides 100 mg of guaifenesin per 5 mL (teaspoon).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05763449
Source datasetuspto-grants-1998_06
ORD IDord-66703a0f2bae41ba8bce66d2de9beb88
Source noteuspto-grants-1998_06