1-[2-(2,3-Dihydro-benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride → 1-[2-(2,3-Dihydro-benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride

HRID 963214Notes

Reaction equation

HRID 963214 reaction equation
[ClH:1].[S:2]1[CH2:6][CH:5]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=3)[CH2:11][CH:10]2[CH3:23])[C:4]2[CH:24]=[CH:25][CH:26]=[CH:27][C:3]1=2.[CH3:28]OC1C(N2CCNC(C)C2)=NC=CC=1>>[ClH:1].[S:2]1[CH2:6][CH:5]([CH:7]([CH3:28])[CH2:8][N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=3)[CH2:11][CH:10]2[CH3:23])[C:4]2[CH:24]=[CH:25][CH:26]=[CH:27][C:3]1=2

Participants

3

Reactant 2

HCID 99531371-[2-(2,3-Dihydro-benzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochlorideHCID 190814811-(3-Methoxy-2-pyridinyl)-3-methylpiperazine

Product 1

HCID 190814361-[2-(2,3-Dihydro-benzo[b]thien-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride

Procedure

The title compound was prepared (48%, mp 167°-170° C.) in a manner analogous to the preparation of 1-[2-(2,3-dihydrobenzo[b]thien-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)-2-methylpiperazine hydrochloride (Example 6) by the reaction of 2,3-dihydro-3-benzo[b]-thienepropanol tosylate with 1-(3-methoxy-2-pyridinyl)-3-methylpiperazine.

Sources & evidence

ORD record
ord-cdaeb14aeadd46ee86284ca07ed7b8de
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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