1-(3-Methoxypyridin-2-yl)piperazine → 1-[2-(5-Chlorobenzo[b]furan-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

HRID 963222Notes

Reaction equation

HRID 963222 reaction equation
Cl.[Cl:2]C1C=CC2OC=C(CCC[N:13]3[CH2:18][CH2:17][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:15][CH2:14]3)C=2C=1.S(O[CH2:40][CH2:41][C:42]1[C:43]2[CH:50]=[C:49]([Cl:51])[CH:48]=[CH:47][C:44]=2[O:45][CH:46]=1)(C1C=CC(C)=CC=1)(=O)=O.COC1C(N2CCNCC2)=NC=CC=1>>[ClH:2].[Cl:51][C:49]1[CH:48]=[CH:47][C:44]2[O:45][CH:46]=[C:42]([CH2:41][CH2:40][N:13]3[CH2:14][CH2:15][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][N:20]=4)[CH2:17][CH2:18]3)[C:43]=2[CH:50]=1

Participants

4

Reactant 3

HCID 127904951-(3-Methoxypyridin-2-yl)piperazineHCID 190814941-[3-(5-Chlorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochlorideHCID 190815105-Chloro-3-benzo[b]furanethanol tosylate

Product 1

HCID 190814281-[2-(5-Chlorobenzo[b]furan-3-yl)ethyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Procedure

The title compound was prepared (0.55 g, 63%, mp 217°-220° C.) in a manner analogous to the preparation of 1-[3-(5-chlorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine (Example 25) by the reaction of 5-chloro-3-benzo[b]furanethanol tosylate with 1-(3-methoxy-2-pyridinyl)piperazine.

Sources & evidence

ORD record
ord-dafd02476d1d4ae5acd1bf40c84d147b
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

Loading…