5-Methoxy-4-(piperazin-1-yl)pyrimidine → HCID 19081511, compound

HRID 963223Notes

Reaction equation

HRID 963223 reaction equation
[ClH:1].[F:2][C:3]1[CH:28]=[CH:27][C:6]2[O:7][CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23]C=[CH:21][N:20]=4)[CH2:15][CH2:14]3)[C:5]=2[CH:4]=1.S(OCCCC1C2C=C(F)C=CC=2OC=1)(C1C=CC(C)=CC=1)(=O)=O.COC1C(N2CCNCC2)=[N:57]C=NC=1>>[ClH:1].[F:2][C:3]1[CH:28]=[CH:27][C:6]2[O:7][CH:8]=[C:9]([CH2:10][CH2:11][CH2:12][N:13]3[CH2:14][CH2:15][N:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][N:57]=[CH:21][N:20]=4)[CH2:17][CH2:18]3)[C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 104201525-Methoxy-4-(piperazin-1-yl)pyrimidineHCID 190814335-Fluoro-3-benzo[b]furanpropanol tosylateHCID 190814511-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride

Product 1

HCID 19081511HCID 19081511, compound

Procedure

The title compound was prepared (0.31 g, 87%, mp 196°-198° C.) in a manner analogous to the preparation of 1-[3-(5-fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride (Example 20) by the reaction of 5-fluoro-3-benzo[b]furanpropanol tosylate with 1-(5-methoxy-4-pyrimidinyl)piperazine.

Sources & evidence

ORD record
ord-510bb6ee31a74484b85890bad8b63e49
Source dataset
uspto-grants-1998_06
Patent number
US05763444

Reaction notes

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