HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-methoxyphenol → 5-Methoxy-3-benzo[b]furanpropanol tosylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-methoxyphenol | HCID 297382 | — |
| Reactant | 5-Methoxy-4-(piperazin-1-yl)pyrimidine | HCID 10420152 | — |
| Reactant | 5-Methoxy-3-benzo[b]furanpropanol tosylate | HCID 19081430 | — |
| Reactant | 5-Fluoro-3-benzo[b]furanpropanol tosylate | HCID 19081433 | — |
| Reactant | 1-[3-(5-Fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride | HCID 19081451 | — |
| Product | 5-Methoxy-3-benzo[b]furanpropanol tosylate | HCID 19081430 | — |
| Product | 1-[3-(5-Methoxybenzo[b]furan-3-yl)propyl]-4-(5-methoxy-4-pyrimidinyl)piperazine hydrochloride | HCID 19081483 | — |
Reaction Steps
The title compound was prepared (0.31 g, 87%, mp 196°-198° C.) in a manner analogous to the preparation of 1-[3-(5-fluorobenzo[b]furan-3-yl)propyl]-4-(3-methoxy-2-pyridinyl)piperazine hydrochloride (Example 20) by the reaction of 5-methoxy-3-benzo[b]furanpropanol tosylate with 1-(5-methoxy-4-pyrimidinyl)piperazine. 5-Methoxy-3-benzo[b]furanpropanol tosylate was prepared from 2-bromo-4-methoxyphenol in a manner analogous to the preparation of 5-fluoro-3-benzo[b]furanpropanol tosylate (Example 21).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763444 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-b77381d00285401a877b7e2aee9dbd2d |
| Source note | uspto-grants-1998_06 |