HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((1,1-Dimethylethoxy)methyl)oxirane → 1-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(t-butyloxy)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((1,1-Dimethylethoxy)methyl)oxirane | HCID 24314 | — |
| Reactant | 4-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide | HCID 21845223 | — |
| Catalyst | Phosphonium, ethyltriphenyl-, bromide (1:1) | HCID 73727 | — |
| Product | 1-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(t-butyloxy)propan-2-ol | HCID 21845221 | 78.3% |
Reaction Steps
4-(1,1-dioxo-thiomorpholin-4-yl)phenol (2.3 g, 10 mmol), t-butylglycidyl ether (1.56 g, 12 mmol) and ethyltriphenylphosphonium bromide (0.1 g) are reacted and purified as described for compound 102 to afford a light yellow liquid 2.8 g (78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763144 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-6453af9dcbd8412b93cd5a7643cbbf6e |
| Source note | uspto-grants-1998_06 |