Pyridine → HCID 67557341, compound

HRID 963253Notes

Reaction equation

HRID 963253 reaction equation
C[O:2][C:3]1[CH:21]=[CH:20][C:6](N(OC(C)C(O)C)OC(C)C(O)C)=[C:5](CCC)[CH:4]=1.N1C=CC=CC=1.CN(C1C=CC=CN=1)C.C1(P(Cl)(Cl)=O)C=CC=CC=1.[CH2:50]([O:54][CH2:55][CH:56]1[CH2:63][N:62]([C:64]2[CH:69]=[CH:68][C:67]([O:70][CH2:71]CCCCCCCCCCC)=[CH:66][CH:65]=2)[CH2:61][CH:60]([CH2:83][O:84][CH2:85][CH2:86][CH2:87][CH3:88])[O:59][P:58](=[O:95])(C2C=CC=CC=2)[O:57]1)[CH2:51][CH2:52][CH3:53]>ClCCl>[CH2:50]([O:54][CH2:55][CH:56]1[CH2:63][N:62]([C:64]2[CH:65]=[CH:66][C:67]([O:70][CH3:71])=[CH:68][CH:69]=2)[CH2:61][CH:60]([CH2:83][O:84][CH2:85][CH2:86][CH2:87][CH3:88])[O:59][P:58](=[O:95])([O:2][C:3]2[CH:21]=[CH:20][CH:6]=[CH:5][CH:4]=2)[O:57]1)[CH2:51][CH2:52][CH3:53]

Participants

7

Reactant 5

HCID 1049PyridineHCID 218852-DimethylaminopyridineHCID 69990Phenylphosphonic dichlorideHCID 54485562HCID 54485562, compoundHCID 86752773HCID 86752773, compound

Product 1

HCID 67557341HCID 67557341, compoundYield 16%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

It is prepared from 4-methoxy-N,N-di(2-hydroxy-3-butoxy)-propyl aniline (1.91 g, 5 mmol), pyridine (1,2 g, 15 mmol), dimethylaminopyridine (0.2 g) and phenylphosphonic dichloride (1.1 g, 5.1 mmol) in dichloromethane as described for compound 200 to obtain a pale yellow liquid 0.4 g (16%) and its isomer 0.5 g (19% a pale yellow liquid).

Sources & evidence

ORD record
ord-16eaa4195d7e442292df7c9199eef3c3
Source dataset
uspto-grants-1998_06
Patent number
US05763144

Reaction notes

Loading…